Studies on the synergistic effect of amphotericin B and 5-fluorocytosine on the growth rate of single hyphae ofAspergillus fumigatus by a biocell-tracer system |
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| Authors: | Hideaki Taguchi Makoto Miyaji Kazuko Nishimura Min-Li Xu |
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| Institution: | (1) Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, 260 Chiba, Japan;(2) 3rd Hospital, Beijing Medical University, 100083 Beijing, China |
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| Abstract: | The biocell-tracer system is a microscopical system to measure the growth rate of a single fungal hypha. The synergistic effect of amphotericin B (AMPH) and 5-fluorocytosine (5-FC) on the growth of hyphae ofAspergillus fumigatus was studied by using this system. Although neither 2µg/ml of AMPH nor 250µg/ml of 5-FC alone showed any effect on the hyphal growth, their combination at these concentrations showed a distinct inhibitory activity. The biocell-tracer system is useful for antifungal activity testing in filamentous fungi. |
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| Keywords: | amphotericin B Aspergillus fumigatus biocell-tracer 5-fluorocytosine synergistic effect |
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