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Effect of Hinge Region State on Interaction of Human IgG3 with the Complement System |
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| Authors: | V. M. Tischenko |
| Affiliation: | (1) Institute of Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russia;(2) Institute of Immunological Engineering, Lyubuchany, Moscow Region, 142380, Russia |
| Abstract: | Covalently cross-linked rod-like dimers of human myeloma IgG3 are more efficient in the inhibition of the complement system reaction than compact dimers. This correlates with an increase in the stability of CH2 domains of the immunoglobulin in the state with the rod-like hinge region. |
| Keywords: | third subclass immunoglobulins complement system dimers hinge region compact and rod-like forms |
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