CD38: a NAADP degrading enzyme |
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Authors: | Schmid Frederike Bruhn Sören Weber Karin Mittrücker Hans-Willi Guse Andreas H |
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Affiliation: | Department of Biochemistry and Signal Transduction, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. |
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Abstract: | The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells. |
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