Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor |
| |
| Authors: | Kato Noriyasu Oka Mitsuru Murase Takayo Yoshida Masahiro Sakairi Masao Yamashita Satoko Yasuda Yoshika Yoshikawa Aya Hayashi Yuuji Makino Mitsuhiro Takeda Motohiro Mirensha Yakufu Kakigami Takuji |
| |
| Affiliation: | Central Research Laboratory, Sanwa Kagaku Kenkyusho, Co. Ltd, 363 Shiosaki, Hokusei-cho, Inabe-city, Mie 511-0406, Japan. n_katoh@mb4.skk-net.com |
| |
| Abstract: | In the course of our program for discovery of novel DPP-IV inhibitors, a series of pyrazolo[1,5-a]pyrimidines were found to be novel DPP-IV inhibitors. We identified N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (4a) and described its pharmacological profiles. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
