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Methods for chromatographic determination of amanitins and related toxins in biological samples |
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| Authors: | R. Dorizzi D. Michelot F. Tagliaro S. Ghielmi |
| Affiliation: | Clinical Chemistry Laboratory, Hospital of Legnago, 37045 Legnago Italy Laboratoire de Chimie Appliquée aux Corps Organisés, U.R.A. 401 du C.N.R.S., Chimie et Biochimie des Interactions Fongiques et Microbiennes, Muséum National d'Histoire Naturelle, 63 Rue de Buffon, F-75005 Paris France Institute of Forensic Medicine, University of Verona, Policlinico Borgo Roma, 37134 Verona Italy Institute of Chemistry, School of Medicine, University of Brescia, 25125 Brescia Italy |
| Abstract: | Methods for the chromatographic determination of amanitins, toxins of Amanita phalloides (Fr.), Link mushrooms and related toxins are reviewed; particular emphasis is given to high-performance liquid chromatographic methods. The main chemical and toxicological aspects are discussed, but the focus of the present review is on the analytical problems arising in a laboratory charged with the setting up of a procedure which can direct the appropriate clinical management of an intoxicated patient or solve a forensic case. |
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