Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells |
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Authors: | Karki Pratap IJdo Jacob W. |
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Affiliation: | (1) Inflammation Program and Division of Rheumatology, Department of Internal Medicine, University of Iowa and Veterans Administration Medical Center, 2501 Crosspark Road, MTF E104, Coralville, Iowa City, IA 52241, USA |
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Abstract: | Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium that survives in neutrophils by delaying apoptosis. The human promyelocytic leukemia cell line HL-60 has been the ultimate choice for culturing Anaplasma in vitro. In this study, we assessed the various events of drug-induced apoptosis in A. phagocytophilum-infected HL-60 cells. Anaplasma infection reduced the cell viability and increased the apoptosis in HL-60 cells and staurosporine or etoposide-induced apoptosis was further exacerbated with Anaplasma infection. Altogether our results suggest that A. phagocytophilum infection is proapoptotic in HL-60 cells unlike in neutrophils where it is antiapoptotic. |
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