Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods/+ mice |
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| Authors: | Poirier Christophe Moran Jennifer L Kovanci Ertug Petit Deborah C Beier David R Bishop Colin E |
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| Institution: | 1. Department of Medicine, Vascular Biology Center, Medical College of Georgia, Augusta, Georgia;2. Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;3. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas;4. Department of Veterinary Medicine and Surgery, University of Texas, M.D. Anderson Cancer Center, Houston, Texas;5. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston‐Salem, North Carolina |
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| Abstract: | In mouse, XY embryos are committed to the male sex determination pathway after the transient expression of the Y-linked Sry gene in the Sertoli cell lineage between 10.5 and 12.5 dpc. In the C57BL/6J strain, male sex determination program can be modulated by some autosomal genes. The C57BL/6J alleles at these autosomal loci can antagonize male sex determination in combination with specific Sry alleles. In this report, the authors have identified an effect of these C57BL/6J specific alleles in combination with a mutated Sox9 allele, Sox9(Ods). Authors report the mapping of three of these genetic loci on mouse chromosome 5 and 10 in a backcross of the Ods mutation to the C57BL/6J background. Our study confirms the importance of the strain C57BL/6J for the investigation of the genetic mechanisms that control sex determination. |
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| Keywords: | mouse genetics sex determination Sox9 gene modifiers Ods |
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