Simon metabolites of alpha-tocopherol are not formed via a rate-controlling scission of the 3'C-H bond |
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| Authors: | P J Dutton L A Hughes D O Foster G W Burton K U Ingold |
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| Institution: | Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario. |
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| Abstract: | The major in vivo oxidation products of alpha-tocopherol, alpha-T, are the Simon metabolites, 1 and 2. For these compounds to be formed from alpha-T the polyisoprenoid tail of alpha-T must be oxidatively cleaved at the 3' carbon atom. Comparison of the levels of 2R,4'R,8'R-alpha-(3',3'-2H2)-T and 2R,4'R,8'R-alpha-5,7-(C2H3)2]-T remaining in various tissues of rats which had been preloaded with equal quantities of these two forms of vitamin E following a change to a vitamin E-free diet has shown that there is no statistically significant difference in the rates of loss of these two deuterium-labeled alpha-T's. This demonstrates that the Simon metabolites are not formed by a rate-controlling scission of the 3'C-H bond of alpha-T. |
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