Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs |
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Authors: | Yves A. Lussier Nikolai N. Khodarev Kelly Regan Kimberly Corbin Haiquan Li Sabha Ganai Sajid A. Khan Jennifer Gnerlich Thomas E. Darga Hanli Fan Oleksiy Karpenko Philip B. Paty Mitchell C. Posner Steven J. Chmura Samuel Hellman Mark K. Ferguson Ralph R. Weichselbaum |
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Abstract: | RationaleStrategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy.MethodsWe analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent.ResultsPatients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset.ConclusionOligo- and poly- metastasis are distinct entities at the clinical and molecular level. |
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