Adiponectin induces growth inhibition and apoptosis in cervical cancer HeLa cells |
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| Authors: | Lianying Xie Yongjun Wang Shengyu Wang Na Wu Yuqiang Chen Jianghua Yan |
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| Affiliation: | (1) State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China;(2) Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, Sichuan University, Chengdu, China |
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| Abstract: | Obesity is a known risk factor for postmenopausal cervical cancer. In human, plasma adiponectin (ADPN) levels are inversely associated with obesity. ADPN may influence the pathogenesis of cervical cancer. In this paper, the effects of ADPN on the proliferation of the cervical cancer HeLa cells and its underlying mechanism were studied. We discovered that two ADPN receptors were expressed in HeLa cells and ADPN inhibited the proliferation of HeLa cells. Western-blotting showed that ADPN activated AMP kinase in HeLa cells. Reverse transcriptase-polymerase chain reaction revealed ADPN down-regulated the expression of cell cycle regulators cyclin D1 and c-myc, and induced the expression of p21WAF1/CIP1 and p53. These results indicate that ADPN inhibits proliferation and induces apoptosis of HeLa cells by altering the expression of cell cycle regulators. |
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