EDOTn and MIM, new peptide backbone protecting groups |
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Authors: | Isidro-Llobet Albert Just-Baringo Xavier Alvarez Mercedes Albericio Fernando |
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Institution: | Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028-Barcelona, Spain. |
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Abstract: | In recent years, backbone protection has allowed the synthesis of complex peptidic sequences of high interest by preventing chain aggregation and aspartimides formation. Nevertheless, the backbone protectors currently used have some drawbacks: they are difficult to remove and show high steric hindrance. The new backbone protectors presented in this study (EDOTn and MIM) represent an improvement in both aspects. |
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