Photo-regulated duplex- and triplex-formation of the modified DNA carrying azobenzene. |
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| Authors: | H Asanuma X Liang T Yoshida T Ito M Komiyama |
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| Institution: | Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Japan. |
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| Abstract: | The duplex- and triplex- forming activity of oligonucleotide was photo-regulated by using the isomerization of azobenzene in the side chain. When the azobenzene was isomerized from the trans-form to the cis-form by photo-irradiation, the melting temperatures of the duplex and triplex between the oligonucleotide and its complementary counterpart were significantly lowered. |
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