首页 | 本学科首页   官方微博 | 高级检索  
     


T-2 Toxin as an Emetic Factor in Moldy Corn
Authors:Robert A. Ellison and Frank N. Kotsonis
Abstract:Extracts of Fusarium poae (NRRL 3287) grown either on sterile corn at 8 C or in Richards solution at room temperature were shown to have emetic activity in pigeons at nonlethal concentration under conditions of oral and intravenous administration. The causative agent was found to be T-2 toxin (3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxy-Delta(9)-trichothecene). Oral and intravenous mean toxic dose values for this compound were found to be 0.72 and 0.15 mg/kg, respectively, as compared with an oral mean lethal dose of 2.75 mg/kg. The fact that T-2 toxin causes emesis at nonlethal concentrations may explain, at least in part, the observance of vomiting as a symptom resulting from ingestion of cereal grains infected with toxic Fusarium species containing T-2 or a similar toxin.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号