Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium |
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| Authors: | Jing Zou Rohit Sood Sanjeev Ranjan Dennis Poe Usama A Ramadan Paavo KJ Kinnunen Ilmari Pyykkö |
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| Affiliation: | (1) Department of Otolaryngology, Medical School, University of Tampere, Tampere, Finland;(2) Helsinki Biophysics and Biomembrane Group, Department of Biomedical Engineering and Computational Sciences, Aalto University, Helsinki, Finland;(3) Experimental MRI Laboratory, Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland |
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| Abstract: | Background Treatment of inner ear diseases remains a problem because of limited passage through the blood-inner ear barriers and lack of control with the delivery of treatment agents by intravenous or oral administration. As a minimally-invasive approach, intratympanic delivery of multifunctional nanoparticles (MFNPs) carrying genes or drugs to the inner ear is a future therapy for treating inner ear diseases, including sensorineural hearing loss (SNHL) and Meniere's disease. In an attempt to track the dynamics and distribution of nanoparticles in vivo, here we describe manufacturing MRI traceable liposome nanoparticles by encapsulating gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) (abbreviated as LPS+Gd-DOTA) and their distribution in the inner ear after either intratympanic or intracochlear administration. |
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