BSSF: a fingerprint based ultrafast binding site similarity search and function analysis server |
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| Authors: | Bing Xiong Jie Wu David L Burk Mengzhu Xue Hualiang Jiang Jingkang Shen |
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| Institution: | (1) State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai, 201203, PR China;(2) Department of Applied Mathematics and Statistics, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA;(3) Department of Biochemistry, McGill University, 740 Dr. Penfield Avenue, Montreal, Quebec, H3A 1A4, Canada |
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| Abstract: | Background Genome sequencing and post-genomics projects such as structural genomics are extending the frontier of the study of sequence-structure-function
relationship of genes and their products. Although many sequence/structure-based methods have been devised with the aim of
deciphering this delicate relationship, there still remain large gaps in this fundamental problem, which continuously drives
researchers to develop novel methods to extract relevant information from sequences and structures and to infer the functions
of newly identified genes by genomics technology. |
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