Pathogenic effect of interleukin-17A in induction of Sj?gren's syndrome-like disease using adenovirus-mediated gene transfer |
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| Authors: | Cuong Q Nguyen Hongen Yin Byung Ha Lee Wendy C Carcamo John A Chiorini and Ammon B Peck |
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| Institution: | (1) Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA;(2) Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, E25-545 Cambridge, MA 02139, USA;(3) Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd, Gainesville, FL 32610, USA;(4) Center for Orphan Autoimmune Disorders, University of Florida College of Dentistry, 1600 SW Archer Rd, Gainesville, FL 32610, USA;(5) National Institute of Dental and Craniofacial Research, NIH, 10 Center Drive MSC 1190, 20892 Bethesda, MD, USA;(6) Department of Pathology, Immunology & Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Rd, 32610 Gainesville, FL, USA |
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| Abstract: | Introduction Sj?gren's syndrome (SS) involves a chronic, progressive inflammation primarily of the salivary and lacrimal glands leading
to decreased levels of saliva and tears resulting in dry mouth and dry eye diseases. Seminal findings regarding TH17 cell populations that secrete predominantly interleukin (IL)-17A have been shown to play an important role in an increasing
number of autoimmune diseases, including SS. In the present study, we investigated the function of IL-17A on the development
and onset of SS. |
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