Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats |
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| Authors: | Liesu Meng Wenhua Zhu Congshan Jiang Xiaojing He Weikun Hou Fang Zheng Rikard Holmdahl Shemin Lu |
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| Affiliation: | 1.Department of Genetics and Molecular Biology,Xi'an Jiaotong University School of Medicine,Xi'an,PR China;2.Key Laboratory of Environment and Genes Related to Diseases,(Xi'an Jiaotong University), Ministry of Education,Xi'an,PR China;3.Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics,Karolinska Institute,Huddinge,Stockholm,Sweden |
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| Abstract: | Introduction Toll-like receptors (TLRs) are involved in both innate and adaptive immune responses and are likely to play a complex role in the pathogenesis of human rheumatoid arthritis (RA) and experimental arthritis. The objective of this study was to identify the key TLR in pristane-induced arthritis (PIA), a rat model for RA, and to clarify its roles in the initiation and maintenance of arthritis. |
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