Exact reductions of Markovian dynamics for ion channels with a single permissive state |
| |
Authors: | James P Keener |
| |
Institution: | (1) Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA;(2) Department of Bioengineering and Howard Hughes Medical Institute, University of California, Berkeley, USA; |
| |
Abstract: | We show that the cooperative model for the kinetics of a tetrameric potassium ion channel derived in Nekouzadeh et al. (Biophys
J 95(7):3510–3520, 2008) is an invariant manifold reduction of the full master equation for the channel kinetics. We further
establish the validity of this reduction for ion channel models consisting of multiple independent subunits with cooperative
transitions from a single permissive state to a conducting state. Finally, we conclude that solutions of the reduced model
are globally asymptotically stable solutions of the full master equation system. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|