A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| |
| Authors: | P. J. Trivedi P. S. Patel M. M Brahmbhatt B. P. Patel S. B. Gajjar R. R. Iyer E. H. Parikh S. N. Shukla P. M. Shah S. R. Bakshi |
| |
| Affiliation: | Cell Biology Division, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, India;1Biochemistry Research Division, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, India;2Department of Medical Oncology, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, India |
| |
| Abstract: | t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype. |
| |
| Keywords: | Acute myeloid leukemia cytogenetics fluorescence in situ hybridization |
|
|
