Functional and metabolic changes of guinea pig peritoneal macrophages induced by bacterial vaccines |
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| Authors: | J Takáčová D Kotulová A Kašičková M Ferenčík |
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| Institution: | (1) Department of Clinical Biochemistry, Hospital with Policlinic, 054 11 Levoča, Czechoslovakia;(2) Department of Medical Microbiology and Immunology, Comenius University, 811 08 Bratislava, Czechoslovakia;(3) Institute of Immunology, Comenius University, 811 08 Bratislava, Czechoslovakia |
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| Abstract: | Phagocytic activity of peritoneal macrophages of guinea pigs injected subcutaneously with bacterial vaccines was found to
be increased. The phagocytic index remained unchanged or was decreased. In addition, a decreased candidacidal activity was
observed. Metabolic activation of macrophages, measured by the INT test, was inhibited in unstimulated cells while cells stimulated
with zymosan or opsonized zymosan exhibited higher values of the INT test as compared with control animals. After injection
of vaccines the number of peritoneal macrophages was increased, but the spleen mass decreased.
Translated by I. Miler |
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