| Abstract: | Formulae are developed for computing changes in expected values in a finite population of linkage disequilibrium among neutral genes from more than two loci, although the exact analysis is taken up to only six loci. An essentially haploid model is used. As with two loci, the three-locus disequilibrium declines exponentially at all generations, but for m > 3 loci a matrix has to be constructed to give joint changes in the m-locus disequilibrium and products of disequilibria with fewer loci, for example of two m/2-locus disequilibria. The asymptotic rates of change in multilocus disequilibria depend on the arrangement of genes on the chromosome as well as its total length, but the initial rate of breakdown of disequilibrium from a line cross base is less dependent on the arrangement. With equally spaced loci the asymptotic rate of breakdown of m locus disequilibrium is roughly proportional to m. Although mutation and interference are excluded from the main analysis, it is shown how they can be incorporated. |
