The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors |
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| Authors: | Bordonaro Michael Lazarova Darina L Sartorelli Alan C |
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| Affiliation: | Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA. |
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| Abstract: | |
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| Keywords: | APC, adenomatous polyposis coli CRC, colorectal carcinoma Dkk1, Dickkopf-1 EGFP, enhanced green fluorescent protein GSK-3beta, glycogen synthase-kinase 3beta BCT, beta-catenin-Tcf HDACi, histone deacetylase inhibitors LRP, low-density lipoprotein receptor-related protein NaB, sodium butyrate OA, okadaic acid PBS, phosphate buffered saline sFRP, secreted Frizzled related protein SAHA, suberoylanilide hydroxamic acid Tcf/Lef, T-cell factor/lymphocyte enhancer factor TOP/FOP, ratio of luciferase reporter activity of pTOPFLASH to that of pFOPFLASH TSA, trichostatin A |
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