Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists |
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Authors: | Jin Guangyi Wu Christina C N Tawatao Rommel I Chan Michael Carson Dennis A Cottam Howard B |
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Affiliation: | Moores Cancer Center, University of California, San Diego, La Jolla, 92093-0820, USA. |
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Abstract: | Several 9-benzyl adenine derivatives bearing various substituted amines at the 8-position have been prepared and evaluated for interferon induction in peripheral blood mononuclear cells (PBMC) from healthy human donors. The 8-bromoadenine derivative 5 was used as a versatile intermediate for all substitutions. The most active 8-substituted amino compound was found to be the 8-morpholinoethylamino derivative 19 which had an EC(50) in the submicromolar range. |
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