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Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists |
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| Authors: | Di Fabio Romano Giovannini Riccardo Bertani Barbara Borriello Manuela Bozzoli Andrea Donati Daniele Falchi Alessandro Ghirlanda Damiano Leslie Colin P Pecunioso Angelo Rumboldt Giovanna Spada Simone |
| Affiliation: | GlaxoSmithKline Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy. rdf26781@gsk.com |
| Abstract: | The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat. |
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