High-affinity binding processes for GABA, glycine, and beta-alanine in synaptosome-enriched fractions of rats CNS.

A bicuculline-sensitive component of the binding of GABA and strychnine-sensitive components of the binding of glycine and beta alanine to synaptosome-enriched fractions of rat CNS have been demonstrated in the presence of physiological concentrations of Na+ and other inorganic ions. These processes might be related to synaptic receptors for these inhibitory amino-acids.