| Rho与中枢神经系统轴突再生 |
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| 引用本文： | 于盼盼,徐晓明,陆佩华. Rho与中枢神经系统轴突再生[J]. 生物化学与生物物理进展, 2004, 31(4): 296-298 |
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| 作者姓名： | 于盼盼 徐晓明 陆佩华 |
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| 作者单位： | 1. 上海第二医科大学神经生物学实验室,上海,200025
2. 上海第二医科大学神经生物学实验室,上海,200025;Kentucky Spinal Cord Injury Research Center,Department of Neurological Surgery,University of Louisville,Louisville,KY40292,USA |
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| 摘 要： | Rho是小分子质量GTP酶Rho家族成员，在细胞的一些信号转导途径中起着分子开关的作用.Rho能通过作用于肌动蛋白骨架系统引起轴突生长锥塌陷，从而抑制轴突生长.研究表明，Nogo-A、MAG、OMgp等髓鞘源性的轴突再生抑制分子均可通过激活Rho介导的信号转导途径抑制轴突再生.
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| 关 键 词： | 生长锥，Rho，Rho相关激酶 |
| 收稿时间： | 2003-09-08 |
| 修稿时间： | 2003-11-28 |
Rho and Axonal Regeneration in The Central Nervous System |
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| YU Pan-Pan,XU Xiao-Ming and LU Pei-Hua. Rho and Axonal Regeneration in The Central Nervous System[J]. Progress In Biochemistry and Biophysics, 2004, 31(4): 296-298 |
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| Authors: | YU Pan-Pan XU Xiao-Ming LU Pei-Hua |
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| Affiliation: | Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025, China;Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025, China;Kentucky Spinal Cord Injury Research Center, Department of Neurological Surgery, University of Louisville, Louisville, KY40292, USA;Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025, China |
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| Abstract: | Rho is a member of the Rho family of small GTPase, and acts as a molecular switch in some signal transduction pathway. Rho can induce growth cones collapse and inhibit axonal outgrowth by regulating the actin cytoskeleton. Recent studies have indicated that three myelin-derived inhibitors including Nogo-A,MAG and OMgp all can inhibit axonal regeneration by activating the Rho-mediated signal transduction pathway. |
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| Keywords: | growth cone Rho Rho-associated kinase |
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