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Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists |
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| Authors: | Gfesser Gregory A Zhang Henry Dinges Jurgen Fox Gerard B Pan Jia Bao Esbenshade Timothy A Yao Betty B Witte David Miller Thomas R Kang Chae-Hee Krueger Kathy M Bennani Youssef L Hancock Arthur A Faghih Ramin |
| Affiliation: | Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. greg.gfesser@abbott.com |
| Abstract: | Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model. |
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