A stitch in time: Efficient computation of genomic DNA melting bubbles |
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| Authors: | Eivind Tøstesen |
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| Affiliation: | (1) Department of Tumor Biology, Norwegian Radium Hospital, N-0310 Oslo, Norway;(2) Department of Mathematics, University of Oslo, N-0316 Oslo, Norway |
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| Abstract: | Background It is of biological interest to make genome-wide predictions of the locations of DNA melting bubbles using statistical mechanics models. Computationally, this poses the challenge that a generic search through all combinations of bubble starts and ends is quadratic. |
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