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Synthesis of 2'-spiro ribo- and arabinonucleosides |
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| Authors: | Babu B Ravindra Keinicke Lise Wengel Jesper |
| Affiliation: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. |
| Abstract: | Four conformationally restricted bicyclic 2'-spiro nucleosides were synthesised and incorporated into oligonucleotides. These spiro nucleotides induced decreased duplex thermostabilities. |
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