Inhibition of gene expression by peptide nucleic acids in cultured cells |
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| Authors: | Cogoi Susanna Rapozzi Valentina Xodo Luigi E |
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| Affiliation: | Department of Biochemical Sciences and Technologies, Udine, Italy. |
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| Abstract: | We have tested in cultured cells the capacity of antisense and antigene PNAs to inhibit, in a sequence specific manner, the expression of oncogenes in leukaemia and pancreatic carcinoma cells. The results observed appeared promising and suggest that PNA may play in the future an important role in targeting disease-related genes. |
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