Phosphono peptide nucleic acids with a constrained hydroxyproline-based backbone |
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Authors: | Efimov Vladimir A Klykov Valeryi N Chakhmakhcheva Oksana G |
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Affiliation: | Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. eva@mail.ibch.ru |
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Abstract: | DNA mimics representing negatively charged analogues of peptide nucleic acids (PNAs), particularly hetero-oligomers constructed from alternating phosphono-PNA residues (pPNA) and monomers on the base of trans-4-hydroxy-L-proline (HypNA) as well as mimics composed of phosphono-HypNA monomers (pHypNA) were tested in a set of in vitro and in vivo assays, and they demonstrated a high potential for the use in nucleic acid based diagnostic, isolation of nucleic acids and antisense experiments. |
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