Stannylation approach to the synthesis of 2'- and 3'-substituted analogues of 2',3'-didehydro-2',3'-dideoxynucleosides |
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Authors: | Kumamoto Hiroki Onuma Sayoko Tanaka Hiromichi |
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Affiliation: | School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, Japan. |
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Abstract: | Three methods are described for the introduction of a tributylstannyl group to the sp2-carbon of 2',3'-didehydro-2',3'-dideoxy nucleosides (d44Ns). The resulting stannylated products serve as versatile intermediates for the synthesis of d4Ns having various types of carbon-substituent. |
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