Synthesis and triplex binding properties of oligonucleotides containing a novel nucleobase |
| |
Authors: | Lecubin Florence Devys Michel Fourrey Jean Louis Sun Jian-Sheng Benhida Rachid |
| |
Affiliation: | Institut de Chimie des Substances Naturelles, CNRS, 91198, Gif sur Yvette, France. |
| |
Abstract: | The thiazolo-indole compound 1 bearing the complementary donor-acceptor-donor sites (dad) was designed for specific recognition of an AT inverted base pair in pyrimidine triple helix motif. It was successfully incorporated into 14-mer oligonucleotide using a serinol unit as sugar derivative. The triple helix hybridization studies were examined by means of thermal denaturation experiments with a 26-mer DNA duplex containing the AT inverted base pair. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|