SATE (aryl) phosphotriester series. II. Stability studies and physicochemical parameters |
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| Authors: | Coussot G Lefebvre I Dimalta D Peyrottes S Pompon A Gosselin G Périgaud C |
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| Affiliation: | Université Montpellier II, UMR 5625 CNRS, Montpellier, France. |
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| Abstract: | The stability of phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and various aryl residues derived from L-tyrosine was evaluated in biological media. The results demonstrate that such compounds give rise to intracellular delivery of the parent mononucleotide through esterase and phosphodiesterase hydrolytic steps, successively. |
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