Novel base-labile protecting groups for 5'-hydroxy function in solid-phase oligonucleotide synthesis |
| |
| Authors: | Kamaike Kazuo Namiki Takashi Kawashima Etsuko |
| |
| Affiliation: | School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan. kamaikek@ps.toyaku.ac.jp |
| |
| Abstract: | The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMMoNBz) and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMMpNBz) groups were developed as novel base-labile protection for the 5'-hydroxy function in solid-phase oligonucleotide synthesis. A comparative study of the LMMoNBz, LMMpNBz and 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting groups for oligonucleotide synthesis proved strong feasibility for the LMMoNBz group. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
