4-Guanidino-2-pyrimidinone nucleobases: synthesis and hybridization properties |
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Authors: | Robles J Grandas A Pedroso E |
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Institution: | Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Barcelona, Spain. jrobles@qo.ub.es |
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Abstract: | N-Alkylated 4-guanidino-2-pyrimidinone-containing nucleosides, in which the guanidine group mimics the double hydrogen bond donor pattern of protonated cytosine, were introduced in polypyrimidine sequences to explore their triple-helix forming capabilites. UV and CD melting experiments showed that strands containing these base analogues did not form triplex complexes. |
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