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Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A |
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| Authors: | Moon Hyung Ryong Kwon Sung Hee Lee Jeong Ah Yoo Byul Nae Kim Hea Ok Chun Moon Woo Kim Hee-Doo Kim Joong Hyup Jeong Lak Shin |
| Institution: | College of Pharmacy, Ewha Womans University, Seoul, South Korea. |
| Abstract: | A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed. |
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