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Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase |
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| Authors: | Jeong Lak Shin Moon Hyung Ryong Park Jae Gyu Shin Dae Hong Choi Won Jun Lee Kang Man Kim Hea Ok Chun Moon Woo Kim Hee-Doo Kim Joong Hyup |
| Institution: | College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr |
| Abstract: | Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase. |
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