Alpha-LNA (alpha-D-configured locked nucleic acid) |
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| Authors: | Christensen Nanna K Petersen Michael Vester Birte Nielsen Poul |
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| Institution: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. |
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| Abstract: | Two pyrimidine alpha-LNA nucleoside monomers have been synthesised and incorporated into alpha-configured oligonucleotides. A fully modified mixed alpha-LNA sequence displays unprecedented parallel stranded hybridisation with complementary RNA and a remarkable selectivity for RNA over DNA. Modelling shows alpha-LNA:RNA to form an extended duplex with a very broad major groove. |
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