|
|||||
|
|
Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity |
|
| Authors: | Kohgo Satoru Yamada Kohei Kitano Kenji Sakata Shinji Hayakawa Hiroyuki Nameki Daisuke Kodama Eiichi Matsuoka Masao Mitsuya Hiroaki Ohrui Hiroshi |
| Institution: | Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan. kogo@yamasa.com |
| Abstract: | Purine 2'-deoxynucleosides bearing an ethynyl or a cyano group at C-4' of the sugar moiety were synthesized from the corresponding 2'-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |