Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides |
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| Authors: | Gu Ping Morral Jordi Wang Jing Rozenski Jef Busson Roger Van Aerschot Arthur De Clercq Erik Herdewijn Piet |
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| Institution: | Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. |
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| Abstract: | A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2. |
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