Structural characterization of LNA and alpha-L-LNA hybridized to RNA |
| |
| Authors: | Petersen Michael Nielsen Jakob T Bondensgaard Kent Wengel Jesper Jacobsen Jens Peter |
| |
| Affiliation: | Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. mip@chem.sdu.dk |
| |
| Abstract: | LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we present a short overview of the structural results we have obtained for LNA:RNA and alpha-L-LNA:RNA hybrids. Specifically, we have shown that LNA acts as an A-type mimic, while alpha-L-LNA acts as a B-type mimic when built into oligonucleotides. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
