Thionucleotides as inhibitors of ribonucleotide reductase |
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| Authors: | Roy B Chambert S Lepoivre M Décout J L |
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| Affiliation: | Institut de Biochimie Biophysique Moléculaire et Cellulaire, Université de Paris Sud, UMR CNRS 8619, Orsay, France. |
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| Abstract: | Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoid CEM/SS cell line. |
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