Oligonucleotides containing an acridine group covalently bonded to the nucleotide flanking the 3'-3' phosphodiester junction for alternate strand triple helix formation |
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| Authors: | Catalanotti Bruno Fattorusso Caterina Mayol Luciano Oliviero Giorgia Piccialli Gennaro Varra Michela |
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| Institution: | Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Napoli, Italy. |
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| Abstract: | Oligonucleotides with a 3'-3' inversion of polarity and containing an acridine group attached to nucleotide base flanking the 3'-3' phosphodiester bon have been synthesized, characterized and used as third strand in alternate triple helix formation. CD melting studies and molecular mechanics calculations have been carried out to investigate these triplex structures. |
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