Recognition of cyclonucleoside lesions by the Lactococcus lactis FPG protein |
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| Authors: | Muller Evelyne Gasparutto Didier Castaing Bertrand Favier Alain Cadet Jean |
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| Affiliation: | Laboratoire des Lésions des Acides Nucléiques, Service de Chimie Inorganique et Biologique and UMR 5046, DRFMC-CEA/Grenoble, Grenoble, France. |
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| Abstract: | Several purine and pyrimidine cyclonucleosides were found to be not recognized by several Escherichia coli and yeast DNA N-glycosylases. Interestingly, a non covalent complex was observed between the Lactoccocus lactis formamidopyrimidine-DNA glycosylases (Fpg-Ll) and the cyclonucleosides. This may provide new information on the mechanism involved in the activity of the latter enzyme. |
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