Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with multisubstrate analogue inhibitor with 2,6-diaminopurine aglycone |
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Authors: | Koellner Gertraud Stroh Albrecht Raszewski Grzegorz Holý Antonin Bzowska Agnieszka |
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Affiliation: | Institut für Chemie-Kristallographie, Freie Universit?t Berlin, Berlin, Germany. |
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Abstract: | The crystal structure at 2.05 A resolution of calf spleen PNP complexed with stoichiometric concentration of acyclic nucleoside phosphonate inhibitor, 2,6-diamino-(S)-9-[2-(phosphonomethoxy)propyl]purine, in a new space group P2(1)2(1)2(1) which contains two full trimers in the asymmetric crystal unit is described. |
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