Synthesis and energy transfer efficiency of FRET terminators derived from different linkers |
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| Authors: | Kumar Shiv Nampalli Satyam Finn Patrick J Sudhakar Rao T Chen Chung-Yuan Flick Parke K Fuller Carl W |
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| Institution: | Amersham Biosciences, Piscataway, New Jersey 08855-1327, USA. shiv.kumar@amersham.com |
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| Abstract: | A number of different energy transfer dye labeled-cassettes were synthesized using aminoacid based trifunctional linkers and coupled to the propargylamino-substituted dideoxynucleoside-5'-triphosphates (ddNTPs). These terminators were evaluated for their energy transfer efficiency and DNA sequencing potential using thermostable DNA polymerase. |
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