Endogenous GABAergic modulators in the pathogenesis of hepatic encephalopathy |
| |
Authors: | Jeffrey D. Rothstein Marjut Olasmaa |
| |
Affiliation: | (1) Department of Neurology, Johns Hopkins University, 600 North Wolfe Street, 21205 Baltimore, MD;(2) FIDIA Georgetown Institute for the Neurosciences, 20007 Washington DC |
| |
Abstract: | Theories on the neurochemical etiology for hepatic encephalopathy have recently focussed on activation of inhibitory neurotransmitter GABA systems. Modulators of the GABAA receptor complex, including diazepam binding inhibitor, are significantly and selectively altered in hepatic encephalopathy. In animals and humans, benzodiazepine receptor antagonists rapidly ameliorate this syndrome suggesting the possible existence of an endogenous benzodiazepine-like substance. Endogenous GABAergic modulators may contribute to the neurochemical pathogenesis of hepatic encephalopathy.Special issue dedicated to Dr. Erminio Costa |
| |
Keywords: | Hepatic encephalopathy GABA DBI benzodiazepine cerebrospinal fluid |
本文献已被 SpringerLink 等数据库收录! |