Aureolysin of Staphylococcus warneri M accelerates its proteolytic cascade,and participates in biofilm formation |
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| Authors: | Ken-ji Yokoi Shinya Kuzuwa Shu-Ichi Iwasaki Ayanori Yamakawa Akira Taketo Ken-Ichi Kodaira |
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| Affiliation: | 1. Food Biochemistry Division, Toyama prefectural Food Research Institute, Toyama, Japan;2. Molecular Biology Group, Faculty of Engineering, Toyama University, Toyama, Japan;3. Quality Control Group, White Food Industry Co. Ltd., Nanto, Japan;4. Biochemistry Division, Department of Material Science, Wakayama National College of Technology, Wakayama, Japan;5. Department of Applied Physics and Chemistry, Fukui University of Technology, Fukui, Japan |
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| Abstract: | The aureolysin (Aur) gene of S. warneri M (aurWM) was cloned and sequenced. Analyses of the aurWM-inactivated mutant (S. warneri Mau) suggested that AurWM was probably associated with efficient processing of the PROM protease (homolog of V8/SspA serine protease), whereas considerable amount of mature-PROC protease (homolog of SspB cysteine protease) accumulated without AurWM. Additionally, AurWM appeared to affect biofilm formation in an uncertain suppressive way. |
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| Keywords: | aureolysin metalloprotease biofilm SspA Staphylococcus warneri |
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