The preventive effect of fish oil on abdominal aortic aneurysm development |
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Authors: | Hirona Kugo Youhei Mouri Hiroki Tanaka Kenichi Yanagimoto Tetsumei Urano |
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Affiliation: | 1. Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University, Nara, Japan;2. Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Japan;3. Human Life Science R&4. D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan |
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Abstract: | Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta and high rupture‐related mortality rates. AAA is histologically characterized by oxidative stress, chronic inflammation, and extracellular matrix degradation in the vascular wall. We previously demonstrated that aortic hypoperfusion could cause the vascular inflammation and AAA formation. However, the preventive method for hypoperfusion‐induced AAA remains unknown. In this study, we evaluated the effect of fish oil on AAA development using a hypoperfusion‐induced AAA animal model. Dilation of the abdominal aorta in the fish oil administration group was smaller than in the control group. Collagen destruction and oxidative stress were suppressed in the fish oil administration group than in the control group. These results suggested that fish oil could prevent the development of AAA induced by hypoperfusion. |
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Keywords: | fish oil EPA abdominal aortic aneurysm MMP2 MMP9 |
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